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Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about Buy Viagra Online Without Prescription 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent Free Sample Of Viagra in the urine (around 13% of the administered oral dose). If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.

Seventy-two percent, 80%, Purchase Viagra Online India and 85% of the patients on 25 mg, 50 mg, and 100 mg of VIAGRA, respectively, achieved erections hard enough for sex, compared to 50% on placebo. Also, men taking VIAGRA showed an improvement in their ability to get and keep an erection versus those who took placebo.

VIAGRA (sildenafil citrate), an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific what is the side effects of Viagra tablets phosphodiesterase type 5 (PDE5).

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More than 20 million men around the world use it When Was Viagra Made regularly. Medicine Like Viagra In the U.S., one out of every five men over 40 has tried it. An average of nine Viagra pills are dispensed every second.

Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs cheap Viagra com . Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply lowest price generic Viagra of blood to the lungs and reduce the workload of the heart.

It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett. Since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction.

The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Based on efficacy and tolerability, countries Viagra over counter the dose may be increased to 100 mg or decreased to 25 mg. The maximum recommended dose is 100 mg. The maximum recommended dosing frequency is once per day. If VIAGRA is taken with food, the onset of activity may be delayed compared to the fasted state.

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Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to

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that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).